Fisetin Powder

The Extract Factory is a specialized manufacturer and wholesale supplier of high-purity Fisetin Powder, operating from a cGMP-aligned production facility in China. We supply bulk botanical extracts to nutraceutical brands, formulation houses, and distribution partners worldwide, combining competitive wholesale pricing with rigorous quality assurance. If you are sourcing a consistent, traceable, and specification-ready fisetin ingredient for anti-aging, antioxidant, or cellular support product lines, our Cotinus coggygria–derived extract is engineered to meet demanding B2B standards.

The Active Constituent: Understanding Fisetin

Fisetin is a naturally occurring flavonol—a subclass of polyphenolic flavonoids—found in only a limited number of botanical species. Among commercial sources, Cotinus coggygria (European smoketree) stands out as one of the most efficient and reliable raw materials for industrial-scale extraction of high-assay fisetin. Unlike multi-flavonoid blends, our process isolates and concentrates this single active compound, preserving its natural molecular structure while removing unnecessary plant co-extractives.

Researchers and formulators value fisetin for its role in senolytic science, oxidative stress management, and cellular longevity pathways. Its integration into dietary supplements, functional nutrition products, and advanced cosmeceutical formulations has accelerated alongside growing consumer interest in healthy aging and mitochondrial health.

Chemical & Physical Characteristics

These physicochemical properties inform formulation strategy. Because Fisetin Powder exhibits limited aqueous solubility and a distinct bitter profile, encapsulation, tablet compression, or lipid-delivery systems are typically recommended for finished consumer products. Our technical team can advise on particle-size customization and compatibility testing to streamline your development timeline.

Botanical Source & Manufacturing Excellence

Raw Material Origin & Authentication

We utilize authenticated Cotinus coggygria plant material as the exclusive raw material for this extract. Prior to processing, botanical identity is verified through macroscopic and microscopic evaluation to prevent adulteration and ensure species purity. This level of incoming material control is foundational to achieving batch-to-batch consistency in a market where fisetin content can vary widely between generic suppliers.

Extraction & Purification Workflow

Our production protocol is designed specifically for fisetin retention and refinement:

1. Preparation — Raw plant material is thoroughly washed to remove soil and environmental impurities, then gently dried at temperatures below 60°C to prevent thermal degradation of heat-sensitive flavonoids.
2. Size Reduction — Dried material is milled into a uniform powder to maximize surface area for efficient solvent contact.
3. Solvent Extraction — The powdered biomass undergoes targeted solvent extraction using food-grade compatible solvents such as ethanol, methanol, or purified water, depending on the target specification.
4. Concentration — The resulting liquid extract is concentrated using rotary evaporation under controlled vacuum and temperature parameters.
5. Drying & Standardization — The concentrate is dried into a solid extract and subjected to multi-step purification, yielding standardized Fisetin Powder at 50%, 85%, or up to 98% purity by HPLC.

This dedicated fisetin-focused workflow avoids the variability common in generic mixed-flavonoid extracts, giving formulators a single-ingredient solution with predictable performance.

Quality Control & Regulatory Alignment

Quality is not a single test but an integrated system. Our Fisetin Powder undergoes comprehensive analytical profiling before release:

Potency & Physicals

• Fisetin Purity (HPLC): ≥98% (with 50% and 85% tiers available for cost-optimized projects)
• Bulk Density: ~0.45 g/mL
• Moisture (Drying Oven): ≤1.0%
• Ash Content: ≤0.5%

Microbial Safety

• Total Plate Count: <10 CFU/g
• Yeasts & Molds: <10 CFU/g
• Salmonella: Not Detected (Absent/25g)
• Escherichia coli: Not Detected (Absent/25g)
• Staphylococcus aureus: Not Detected (Absent/25g)

Heavy Metals (AAS)

• Arsenic (As): <2 ppm
• Lead (Pb): <2 ppm
• Cadmium (Cd): <1 ppm
• Mercury (Hg): <0.1 ppm

Additional screening for pesticide residues is conducted to confirm the extract is free from harmful agrochemical contaminants. All manufacturing operations adhere to current Good Manufacturing Practices (cGMP), and the finished Fisetin Powder is evaluated against pharmacopoeial quality benchmarks, including standards aligned with the United States Pharmacopeia (USP) and the European Pharmacopoeia (Ph. Eur.).

Functional Applications & Nutraceutical Formulation Guidance

Fisetin Powder is positioned across multiple high-growth nutraceutical categories. The following application profiles and usage ranges reflect typical incorporation levels referenced in product development for premium dietary supplements:

Anti-Inflammatory & Oxidative Stress Modulation

Fisetin is studied for its ability to modulate inflammatory mediators and scavenge free radicals. For antioxidant-focused formulas, developers typically specify ≥98% purity with target daily inclusion levels of 50–200 mg. Anti-inflammatory positioning frequently utilizes ≥95% purity at 50–100 mg/day inclusion rates.

Neuroprotection & Cognitive Support

Preclinical interest in fisetin centers on its potential influence on brain-derived neurotrophic factor (BDNF) and neuroprotective signaling. Formulations in this category generally specify ≥95% purity and incorporate 100–250 mg/day.

Healthy Aging & Senolytic Positioning

As a prominent ingredient in longevity science, fisetin is incorporated into products targeting cellular senescence and sirtuin activation. ≥95% purity grades are standard, with typical formulation targets of 50–200 mg/day.

Metabolic & Mitochondrial Health

Fisetin is included in metabolic support blends for its researched effects on insulin sensitivity and mitochondrial function. High-assay ≥98% material is preferred here, with inclusion levels commonly at 100–250 mg/day.

Skin Health & Nutricosmetics

For beauty-from-within and UV-defense applications, fisetin is valued for its potential role in reducing collagen breakdown and addressing inflammatory skin pathways. ≥95% purity is typically used at 50–150 mg/day.

Cardiovascular Support

Formulations targeting vascular function and lipid metabolism often leverage ≥98% purity fisetin, with development dosage ranges of 100–250 mg/day.

Note: All dosage figures represent standard industry formulation references. Finished product claims and serving sizes must be validated according to local regulatory requirements in the target market.

Market-Ready Synergistic Combinations

Fisetin Powder integrates effectively into a wide spectrum of combination formulas. Understanding these pairings helps formulators build differentiated, clinically positioned products:

The Extract Factory supports OEM and ODM development for these and other custom combinations, providing pre-blended powders, granules, or finished dosage forms.

Packaging, Storage & Supply Specifications

Available Specifications

We manufacture Fisetin Powder in three standardized assay tiers to align with different price points and formulation requirements:

• 50% Fisetin — Cost-effective for bulk blends and functional foods
• 85% Fisetin — Mid-tier purity for balanced performance and cost
• 98% Fisetin — Ultra-pure grade for clinical-positioned supplements and precise dosing

Packaging

Bulk Fisetin Powder is supplied in food-grade, multi-layer packaging—typically aluminum foil bags inner-lined with polyethylene, packed into fiber drums. Common wholesale sizes include 1 kg, 5 kg, and 25 kg, with custom packaging available upon request.

Storage & Stability Recommendations

To maintain long-term stability and potency:

• Store in a cool, dry warehouse environment.
• Protect from direct sunlight, heat, and moisture.
• Keep containers tightly sealed when not in use.
• Minimize exposure to ambient air to prevent oxidative degradation or hygroscopic clumping.

When stored under these recommended conditions, Fisetin Powder exhibits excellent chemical stability, meeting the rigorous shelf-life expectations of international nutraceutical distribution networks.

Why Partner With The Extract Factory?

Source Specificity & Supply Security
We focus exclusively on authenticated Cotinus coggygria raw material, eliminating the cross-contamination and potency drift common in multi-source botanical operations. Our closed-loop traceability ensures you know the origin, processing history, and analytical profile of every batch.

Process Control for Precision Formulation
Rather than offering a generic mixed extract, our production line is optimized specifically for fisetin isolation. The result is a higher true assay, reliable batch homogeneity, and material that behaves predictably in capsule, tablet, and powder blend applications.

Customization & OEM/ODM Agility
Beyond bulk extract supply, we function as a formulation partner:

• Custom particle sizing and bulk density adjustment
• Tailored assay levels (50%, 85%, or 98%)
• Finished dosage development (capsules, tablets, sachets)
• Pre-formulated blends with synergistic actives
• Label-ready technical documentation for global compliance

Wholesale Economics Without Compromise
Our vertically integrated manufacturing model enables competitive bulk and wholesale pricing on Fisetin Powder, supported by international quality certifications and a longstanding reputation in the plant extract supply sector.

Request a Quotation or Technical Datasheet

For manufacturers, brands, importers, and distributors seeking a dependable supply of high-purity Fisetin Powder, The Extract Factory offers the technical rigor and supply chain stability your product line demands.

To discuss bulk pricing, obtain a current Certificate of Analysis (COA), request a sample, or explore custom formulation services, please contact our team directly at [email protected].

Samantha Harris