The Extract Factory is a trusted manufacturer and bulk supplier of high-purity Andrographolide Powder in China. Leveraging advanced extraction capabilities and rigorous quality protocols, we produce a standardized botanical extract that meets the exacting demands of pharmaceutical developers, nutraceutical brands, cosmetic formulators, and agricultural-input manufacturers worldwide. Our Andrographolide Powder is competitively priced for wholesale and bulk procurement, with consistent batch-to-batch reliability supported by comprehensive analytical documentation.
Botanical Source & Standardized Extraction
Andrographolide is a naturally occurring labdane diterpenoid isolated from the aerial parts—principally the leaves and stems—of Andrographis paniculata (Burm. f.) Nees, a medicinal herb widely cultivated across subtropical and tropical growing regions. At The Extract Factory, we select premium, non-GMO botanical raw materials that have not undergone chemical synthesis or genetic modification. This preserves the inherent phytochemical integrity of the plant and ensures that the final extract delivers the full therapeutic profile traditionally associated with Andrographis paniculata.
Through a precisely controlled extraction and purification workflow, we concentrate the active constituent to yield a white, fine crystalline powder. The product is assigned CAS number 5508-58-7 and conforms to the molecular formula C₂₀H₃₀O₅. By prioritizing standardized processes and full traceability from harvest to final packaging, we provide ingredient security for manufacturers requiring dependable supply chains.
Physical & Chemical Characteristics
| Property | Specification |
|---|---|
| Appearance | White powder |
| Odor | Characteristic Andrographis paniculata aroma |
| Taste | Characteristic Andrographis paniculata taste |
| Bulk Density (Slack) | 0.46 g/mL (USP 616) |
| Particle Size | 95% through 80 mesh (CP 2015) |
| Solubility | Soluble in ethanol, acetone, DMSO, and other organic solvents |
| Storage Stability | Stable when stored in a cool, dark, dry environment |
The light, fine powder texture and neutral white coloration provide significant formulation advantages. Unlike deeply pigmented botanical extracts, this colorless Andrographolide Powder integrates seamlessly into finished products—whether translucent serums, white tablet cores, or clear beverage emulsions—without altering aesthetic appearance. Its favorable solubility profile in polar organic solvents facilitates efficient dissolution during pre-formulation and supports enhanced bioavailability in delivery systems.
Quality Assurance & Analytical Verification
Quality control is integrated at every stage of production. Each lot is subjected to full chemical and microbiological analysis before release.
Chemical Profile
- Andrographolide (HPLC): ≥98% (batch-tested at 98.21%)
- Moisture: ≤1% (0.21%) | CP 2015 (105°, 4h)
- Ash: ≤1% (0.35%) | CP 2015
- Total Heavy Metals: <10 ppm | CP 2015
Microbiological Safety
- Aerobic Bacterial Count: ≤1,000 CFU/g | GB 4789.2
- Yeast: ≤100 CFU/g | GB 4789.15
- Mold: ≤100 CFU/g | GB 4789.15
- Escherichia coli: <3.0 MPN/g | GB 4789.38
- Salmonella: Not Detected | GB 4789.4
- Staphylococcus aureus: Not Detected | GB 4789.10
Our testing regimen utilizes High-Performance Liquid Chromatography (HPLC) for potency verification and infrared spectroscopy for structural confirmation. These analytical methods, combined with in-process checks and final-release protocols, guarantee that every drum of Andrographolide Powder meets predefined specifications for identity, purity, strength, and safety.
Manufacturing Process & Technical Excellence
The production workflow at The Extract Factory is designed to maximize yield while preserving delicate active molecules:
- Raw Material Preparation — Fresh aerial parts are harvested at optimal maturity and inspected for identity and purity before processing.
- Coarse Extraction — Dried biomass is mechanically ground and subjected to controlled maceration using food-grade ethanol. This efficiently liberates diterpenoid lactones from the plant matrix.
- Solid-Liquid Separation & Filtration — The extract is filtered to remove fibrous debris and insoluble impurities, clarifying the solution for downstream concentration.
- Vacuum Concentration — Solvent is recovered under reduced pressure and low temperature, minimizing thermal degradation while increasing the active fraction concentration.
- Crystallization & Recrystallization — Concentrated andrographolide is crystallized from an appropriate solvent system to yield high-purity crystals and reject residual co-extractives.
- Drying & Milling — Crystals are gently dried to eliminate residual solvents and milled to a uniform powder passing 80 mesh.
- Quality Testing & Release — Each batch undergoes HPLC, moisture, ash, heavy metal, and full microbial panels.
- Packaging & Controlled Storage — Finished powder is packed under nitrogen-flushed, light-proof, moisture-barrier packaging and warehoused under climate-controlled conditions.
Functional Properties & Pharmacological Profile
Andrographolide is recognized in phytopharmacology for a broad spectrum of biological activities, including anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, and antitumor properties investigated in preclinical and clinical research. Its mechanisms of action include:
- NF-κB Pathway Modulation — Helps regulate downstream expression of pro-inflammatory cytokines such as TNF-α and IL-6.
- Oxidative Stress Management — Scavenges free radicals and inhibits lipid peroxidation, supporting cellular redox balance.
- Immune Response Support — Enhances activity of immune cells while helping to control excessive inflammatory signaling.
- Dermal Matrix Protection — In cosmetic models, it has been observed to support collagen synthesis, suppress matrix metalloproteinase (MMP) expression, and promote hyaluronic acid production.
- Agricultural Bioactivity — Acts as a natural botanical protectant by interfering with pest nervous systems and fungal cell membranes.
Industry Applications & Recommended Inclusion Levels
The Extract Factory supplies multi-grade Andrographolide Powder refined for distinct verticals, from high-purity cosmetic actives to technical-grade agricultural concentrates.
Nutraceuticals & Dietary Supplements
Ideal for immune-support capsules, liver-health complexes, and anti-inflammatory botanical blends.
Recommended Grade: ≥98% purity
Suggested Use: 200–400 mg per day (formulation dependent; consult applicable regulations)
Cosmetics & Personal Care
Suited for anti-acne toners, barrier-repair creams, and anti-aging serums where color neutrality is critical.
Recommended Grade: ≥99% purity
Suggested Inclusion: 0.1–0.2% of total product weight
Functional Foods & Beverages
Can be incorporated into functional shots, fortified beverages, and wellness food matrices as a natural anti-inflammatory and antioxidant ingredient.
Recommended Grade: ≥95% purity
Suggested Use: 10–20 mg per serving
Agricultural Inputs
Used in organic crop-protection formulations as a botanical insecticide and fungicide intermediate.
Recommended Grade: ≥90% purity
Suggested Inclusion: 0.05–0.1% of total formulation weight
Pharmaceutical Research
Employed as a reference standard and active pharmaceutical ingredient candidate in drug-discovery and preclinical development programs.
Note: Recommended usage levels are provided for formulation guidance only and do not constitute medical or therapeutic advice. Developers should consult qualified professionals and verify compliance with local regulatory requirements.
Packaging, Storage & Shelf Life
To maintain stability from factory to formulation room, The Extract Factory offers flexible packaging configurations:
- Inner Packaging: 1 kg to 5 kg aluminum foil bags with vacuum or nitrogen seal
- Outer Packaging: 25 kg fiber drums or cartons; customized outer packaging available upon request
- Bulk: Larger quantities tailored to commercial manufacturing needs
Storage Recommendations:
Store in a tightly sealed container at room temperature, away from direct light, heat, and moisture. When handled under these conditions, Andrographolide Powder retains stability for 24 months from the date of manufacture or analytical testing.
Certifications & Global Compliance
Our manufacturing ecosystem is supported by internationally recognized quality and ethical standards:
- ISO 22000 Food Safety Management
- HALAL Certified
- KOSHER Certified
- Commodity Inspection Compliance
- Validated Business Licensing for export-grade botanical extraction
These credentials ensure that our Andrographolide Powder is suitable for formulation in markets with stringent religious, safety, and import-compliance requirements.
Why Wholesale Buyers Choose The Extract Factory
- Verified Purity: HPLC-verified ≥98% andrographolide with Certificates of Analysis available per batch.
- Formulation Flexibility: White, low-odor powder compatible with tablets, capsules, topicals, and liquid delivery systems.
- Supply Security: Scalable production volumes and consistent lead times for distributors and long-term procurement contracts.
- Technical Transparency: Full process traceability, from authenticated raw material sourcing to finished-goods release.
- Competitive B2B Pricing: Factory-direct wholesale and bulk pricing without intermediary markups.
Request a Sample or Bulk Quotation
Experience the formulation advantages of The Extract Factory’s Andrographolide Powder. Whether you are developing next-generation immune supplements, clean-label cosmetic actives, or sustainable agrochemical solutions, our technical team is ready to support your specifications.
Contact us today at [email protected] to request a free sample, detailed COA, or competitive wholesale pricing. Discover how a standardized, high-purity Andrographis paniculata extract can strengthen your product portfolio.
